EFFECT OF OXYFEDRINE ON RABBIT PLATELET AGGREGATION AND MDA FORMATION INDUCED BY THROMBIN
- VernacularTitle:奥昔麻黄碱对凝血酶诱导家兔血小板聚集和丙二醛生成的影响
- Author:
Jiemin FU
;
Zengxi LI
;
Shan SHI
- Publication Type:Journal Article
- Keywords:
Oxyfedrine;
Platelet aggregation;
Malondialdehyde;
Thrombin
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Oxyfedrine (Oxy ) exhibited inhibitory effect on washed rabbit platelet aggregation and MDA production induced by thrombin (4 U /ml) . The concentration of Oxy causing 50% inhibition of platelet aggregation induced by thrombin was 254 ?mol/L . Up to 2 nig/ml, acetysalicylic acid (ASA) could not antagonize platelet aggregation induced by thrombin 。 However, ASA 50 ?g/ml reduced the generation of MDA markedly. These results suggest that anti-aggregation of Oxy may be related to inhibition of PAF formation and the effect of Oxy on MDA generation may be due to the inhibition of arachi-donic acid release.
