CHANGE OF T LYMPHOCYTE SUBSETS IN RATS BEARING BERH-2 HEPATOCELLULAR CARCINOMA AND EFFECT OF IMMUNOTHERAPY ON TUMOR IN VIVO
- VernacularTitle:肝癌大鼠T细胞亚群变化和免疫疗法体内抗肿瘤作用
- Author:
Yajun GUO
- Publication Type:Journal Article
- Keywords:
hepatoma;
T lymphocyte subsets;
inferferon;
interleukin-2;
5-fluorouracial;
immunotherapy
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, the changes of peripheral blood and tumor-infiltrating T lymphocyte subsets and the effects of different immunotherapies on tumor in BERH-2 hepatoma-bearing rats were investigated using an immunofluorescent staining method with mouse anti-rat T lymphocyte subsets monoclone antibodies and flow cytometry.The results.indicate that T lymphocyte subsets had an obvious disruption, maily Th subset decreasing and Ts subset increasing.And these changes were closely related with tumor growth and metastasis. Interferon (IFN), 5-fluouriamide (5-FU) and interleukin-2. (IL-2) had no marked inhibitory effect on tumor when, given respectively.However, the tumor invasion and metastasis were prevented and the disorder of T lymphocyte subsets was also improved by a combination of IFN, IL-2 and 5-FU.Immunochemotherapy (IC) has multiple effects against tumor, such as improvement of host immunity and direct killing and inhibition of tumor cells, and is a valuable antitumor therapy.
