CLINICAL STUDY ON IMMUNOCHEMOTHERAPY OF HEPATOCEL-LULAR CARCINOMA
- VernacularTitle:原发性肝癌的免疫化学治疗
- Author:
Yajun GUO
- Publication Type:Journal Article
- Keywords:
hepatoma;
interferon;
interleukin-2;
5-fluorouracil immunotherapy;
chemotherapy
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, 67 cases of hepatocellular carcinoma(HCC)were treated with immunotherapy or immunochemotherapy .The results indicated that natural killer cell(NK)and antibody dependent cytotoxicity cell(ADCC)activitiesand lymphocyte transformation rate(LTR)were significantly improved in vivo after treatment .The NK activity in tumor tissue, which showed a heavy immunosuppression, could be also enhanced and recovered to normal level after treatment with lymp-hokine mixture and 5-fluouriamide(5-FU) .Immunity of host with postoperative immunochemotherapy was rapidly improved and recovery rate was higher,The survival time in these cases of unresectable tumors was obviously prolonged when a general immunotherapy was used only.Immunochemotherapy can improve immunity and inhibite selectively Ts cells as well as kill directly tumor cells.Especially, it can play an important role in the treatment of hepatocellular carcinoma and in the prevention of its recurrence after operation.
