The Relationship between Active Oxygen Radicals and Early Lung Injury after Smoke Inhalation Injury in Goats
- VernacularTitle:山羊烟雾吸入伤后早期肺损伤与活性氧变化的关系
- Author:
Zhuodao ZHAO
- Publication Type:Journal Article
- Keywords:
Lung/injurieSi Superoxide dismutase/analysis;
Burns, inhalation/ physiopathology;
Goat
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
This study observed the relationship between active oxygen radicals and early lung injury after smoke inhalation injury in awake goats (N = I5) with chronic lung lymph fistular. We measured superoxide dismutase (SOD) to demonstrate the active oxygen radicals; Lung lymph flow (QL), lung lymph/plasma total protein and albumin ratio (L/P) , lung lymph total protein clearance (CL) , lung transvascu-lar protein flux, extravascuiar lung water (EVLW) , as well as PaO2 as parameters indicating lung injury.The result demonstrated that during the earlier postinjury period the injuried animals were suffering from hypoxemia, matabolic acidosis and respiratory alkalosis. EVLW and QL increased sharply during the first hour. Interstitial and alveolar edema were seen under microscope. 'These results indicated that the animals develop lung edema and acute respiratory failure. Changs of QL and EVLW were similar to L/P, CL and lung transvascular protein flux; the correlation between L/P and EVLW was significant. These data showed that the pulmonary edema was mainly a permeability one. Changes of active oxygen radicals of lung lymph fluid and arterial blood were earlier than that of venous blood; and active oxygen radicals of arterial blood was slightly higher than that of venous blood. The active oxygen radicals in pulmonary tissue and fluid of lung lavage and the lung lymph SOD clearance increased immidiatly in postinjury. These data suggested that active oxygen radicals were increased and produced in lungs. The active oxygen radicals changed with EVLW, QL, L/P and lung transvascular protein fluxi the correlation between EVLW and active oxygen radicals in pulmonary tissue, fluid of lung lavage, lung lymph SOD clearance and lung transvascular protein flux were all significant. These observations showed that early after smoke inhalation injury active oxygen radicals played a possible role in the development and progression of lung injury and pulmonary edema.
