EFFECTS OF TOTAL GLUCOSIDES OF PAEONY ON CHEMILUMINESCENCE OF PERITONEAL MACROPHAGES IN RATS
- VernacularTitle:白芍总甙对大鼠腹腔巨噬细胞化学发光的影响
- Author:
Junshan LIANG
;
Minzhu CHEN
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
Total glucosides of paeony;
Chemiluminescence;
Macrophage
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Influences of the concentrations of luminol, zymosan & cells and opsonizing time of zymosan on luminol-dependent chemiluminescence( LDCL ) of peritoneal macrophages ( PM?) in rats were investigated by the method of orthogonal analysis. The result showed that the best levels were 100?mol/L of luminol, 10 mg/ml of zymosan, 5? 10~6/ml of cells and 45 min for opsonizing time. The LDCL of PM? was enhanced by incubation with TGP for 12 h in a concentration-dependent manner in the range of 0.09-2.25 ?g/ml of TGP, but LDCL was diminished with the concentration of 11.25 ?g/ml of TGP . The concentration-effect curve seems to be bell-shaped. The data suggested that TGP had two-sided regulatory effects on the LDCL of PM? in rats, depending on the concentration used.
