THE HYPOTENSIVE ACTION OF THE PHOSPHOLIPASE A_2 OF THE BEE VENOM
- VernacularTitle:蜂毒磷脂酶A_2的降压作用
- Author:
Jiliang XU
;
Yulin YANG
;
Zongyao YU
;
Jinhua HUANG
- Publication Type:Journal Article
- Keywords:
Phospholipase A_2 of the bee venom;
Hypotension;
Histamine;
Fluorometry
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The phospholipase A2 ( PLA2 ) is one of the main constituents of the bee venom. Its hypotensive effect and mechanism are studied in this report.In the anaesthetized rats and cats, the PLA2 of the bee venom given intravenously caused a quick and profound fall in the arterial blood pressure.The results of this study indicate that its hypotensive effect is mainly concerned with releasing the endogenous histamine. If the antagonists of H1 and H2 receptor are administered together, its hypotensive action will be countered.
