PROTECTIVE EFFECTS OF METHOXYADIANTIFOLINE ON EXPERIMENTAL ARRHYTHMIAS
- VernacularTitle:峨嵋唐松草碱抗实验性心律失常作用
- Author:
Shaoyu CHENG
;
Yufen LIU
;
Jufang JIA
- Publication Type:Journal Article
- Keywords:
Methoxyadiantifoline;
Aconitine;
Ouabain;
Arrhythmias;
Reperfusion;
Myocardil Ischemia
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Methoxyadiantifoline 10 mg/kg i.v. significantly increased the arrhythmia- inducing dose of aconitine in anaesthetized rats, and that of ouabain in anaesthetized guinea pigs. It markedly prevented ventr icular fibrillation induced by chloroform. Methoxyadiantifoline is also effective in preventing reperfusion-induced arrhythmias in anaesthetized rats. It was demonstrated that methoxyadiantifoline slowed heart rate significantly, and prolonged P-R and Q-Tc interval of ECG in rats.
