DIAGNOSTIC VALUES OF ASSAY FOR ABNORMAL PROTHROMBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA
- VernacularTitle:异常凝血酶原测定对原发性肝癌的诊断价值
- Author:
Zhengfeng YIN
- Publication Type:Journal Article
- Keywords:
abnormal prothrombin;
AFP;
tumor marker;
hepatoma;
diagnosis
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we determined plasma abnormal prothrombin concentrations in 98 patients with histologically-proved primary hepatoceliular carcinoma (HCC) and 181 patients with other diseases using a radio-rocket electrophoresis autography. Out of 98 patients with HCC, 68 had abnormal prothrombin levels above or equal to 250 ?g/L and the positively was 69.4%, which was much higher than that in other groups. Abnormal prothrombin levels correlated poorly with those of alpha-fetoprotein (AFP)(r = 0.317), The positiveties of abnormal prothrombin level in HCC with low AFP level and with AFP negative were 63.8% and 65.5%. respectively. When used in combination, both tests could identify 84.7% of patients with HCC and 84.2% of patients with small HCC, respectively. The results show that the assay for plasma abnormal prothrombin may be useful in diagnosing low AFP-producing or AFP negative HCC, and also in discriminating HCC from chronic liver diseases and benign tumors of liver.
