A Study of Epileptiform Hippocampal Unit Activity Induced by Introcerebroventrocular injection of Kainic Acid in the Awake Rat
- VernacularTitle:清醒大鼠侧脑室内注入红藻氨酸引起海马单位癫痫样电活动的研究
- Author:
Qing GUO
- Publication Type:Journal Article
- Keywords:
Epilapsy, temporal lobe;
Kainic acid;
Epilepsy/chemical induced;
Hippocampus/ drug effects
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
After introcerebroventricular injection of kainic acid(KA) in the awake rat, three types of hippocampal unit responses, i. e- positive units, negative units and indifferent units, were recorded- Most positive units were hippocampal complex spike cells which correspond histologically to hippocampal pyramidal cells, and most hippocampal complex spike cells fired in positive bursts after KA treatment. In the early period after KA injection, the positive units were concentrated in CA3 area. It was suggested that:(1)the activities of positive units may be considered as the typical epileptiform hippocampal unit activity induced by KA, and the firing characteristics of the negative units may be the result of influence of hippocampal inhibitory interneurons or that of the excessive cellular depolarization;(2) the hippocampal pyramidal cells were more sensitive to the epileptogenic effect of KA than the hippocampal interneurons, and some pyramidal cells in CA3 area may serve as "pacemaker neurons" in KA induced epileptogenesis.
