HYPOTHERMAL EFFECT OF TOTAL GLUCOSIDES OF PAEONY ROOT AND PRELIMINARY STUDY OF ITS MECHANISM
- VernacularTitle:白芍总甙降低小鼠和大鼠体温作用及其机理初步探讨
- Author:
Yongxiang WANG
;
Peng CHEN
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
TGPs;
Hypothermia;
Environment temperature;
Lateral ventricie;
Chlopheniramine
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Total glucosides of paeony root ( TGPs ) ( 5 ~40mg/kg, ip ) had a dose-related hypothermal effect in mice and rats, which was related to the environment temperature. But TGPs ( 40mg/kg, ip or iv ) showed no significant hypothermal effect in guinea-pigs or rabbits. TGPs ( 2, 4 mg/kg, icv ) had a potential hypothermal effect in rats. Chlopheniramine had antagonist effect on hypothermal effect of TGPs in mice and rats.
