EFFECT OF SINOMENINE ON THE ISOLATED SUPERIOR CERVICAL GANGLIA OF RABBITS
- VernacularTitle:青藤碱对离体兔颈上交感神经节的作用
- Author:
Hairu HUO
;
Xiping CHE
- Publication Type:Journal Article
- Keywords:
Sinomenine;
Superior cervical sympathetic ganglia;
Sucrose -gap method;
Curare;
Ganglionic block
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of Sin on the transmission of the impulses through isolated rabbit superior cervical sympathetic ganglia in comparison with that of curare by the sucrose - gap method was studied.Inhibi -tory effect of Sin on the action potential was dose-dependent but no effect on the excitability and conductivity of preganglionic nerves. The ID50 of Sin and curare were 1.2 mM and 0.2 mM, respectively. The effect of Sin was reduced in high Ca2+ concentration solution, and enhanced under Ca2+ free solution. Neostigmine antagonized the effect of Sin.
