EFFECTS OF ZINC ON BURNS HEALING AND CORRELATION BETWEEN SERUM ZINC AND SERUM PROTEIN AND ALKALINE PHOSPHATASE IN BURNED RABBITS
- VernacularTitle:锌对兔烧伤愈合的影响及血清锌与血清蛋白和碱性磷酸酶的关系
- Author:
Donglian CAI
- Publication Type:Journal Article
- Keywords:
burn;
zinc;
alkalline phosphatase;
serum protein;
rabbits
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
We report herein effects of varying dietary zinc contents on burns healing and correlation between serum zinc and serum alkaline phosphatase (AKP) activity and serum protein in 15% total body surface area (TBSA) of Ⅲ? burned Lop rabbits, serum zinc concentration in the rabbits given a low zinc diet for 2 weeks and those with burns decreased significantly, and further decreased and failed to return to normal in the rabbit with a low zinc diet and burns. On the contrary, serum zinc was recovered rapidly to normal in the groups fed an adequate zinc diet.Similar changes were found in serum AKP activity.Postburn total serum protein and albumin contents were markedly decreased and did not return to normal on d 15. Burns healing in the high zinc group was over 10 d faster than that in the low zinc group. Serum zinc was found to be well correlated with serum AKP activity and serum protein. These results strongly suggest that zinc migt be a factor benefiting burns healing. We conclude that serum AKP activity could be used as a diagnostic criterion of postburn hypozincemia as well as a valid index in the assessment of the effectiveness of supplemental zinc.
