INFLUENCE OF H_2-RECEPTOR ANTAGONIST ON GASTRIC MUCOUS MEMBRANE AND GASTRIC JUICE IN SEVERE BURNED RATS
- VernacularTitle:H_2受体拮抗剂对严重烫伤大鼠胃粘膜和胃粘液的影响
- Author:
Yulin CHEN
- Publication Type:Journal Article
- Keywords:
H_2-receptor antagonist;
stress ulcer;
burn;
rats
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study, 119 adult wistar rats were used, and divided into four groups (control group, burn group, burn-cimetidine treatment group and burn-ranitidine reatment grup). 20% TBSA full thickness burn was produced by immersion of the clipped back of the rat in 100℃ boiling water for 15s. The rats of the control group were immersed in 37℃ water for 15 s. In the treatment groups, the animals were treated with cimetidine (0.1 mg/g) or ranitidine (0.05 mg/g) intraperitoneally every 12 h, respectively. All animals were given fluid therapy according to the TBSA and body weight. In the animals treated with cimetidine or ranitidine, the H+ concentration of gastric juice was greatly decreased as compared with that of the burn group (P
