Effects of Tetrandrine on Aggregation and Morphological Changes of Platelets in Rabbits
- VernacularTitle:粉防己碱对兔血小板聚集及形态的影响
- Author:
Yueming QIAN
;
Yuehua HUANG
- Publication Type:Journal Article
- Keywords:
Tetrandrine/pharmacodynamics;
Platelet aggregation/drug effect;
Blood platelets/ultrastructure;
Dipyridamole/pharmacodynamics;
Calcium/physiology
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of tetrandrine on the aggregation and morphological changes of platelets were studied by using the rabbit platelet-rich plasma prepared with centri-fugation.It was found that tetrandrine could markedly inhibit the platelet aggregation induced by ADP,collagen,and arachidonic acid with an IC50(50% inhibitory concentration) of 38.9,30.3 and 44.3?g/ml respectively.The platelets pretreated with tetrandrine could not be stimulated to initiate morphological changes and granule release,and their normal structures were well preserved.In addition,di-pyridamole could enhance but excessive amount of extracellular calcium could weaken the inhibition of tetrandrine on platelet aggregation.
