The Relation of Analgesia Induced by Electric Stimulation of Hippocampus with Midbrain Periaqueductal Gray in Rats
- VernacularTitle:电刺激大鼠海马镇痛作用及其与中脑导水管周围灰质的关系
- Author:
Changcheng ZHANG
- Publication Type:Journal Article
- Keywords:
Hippocampus/physiology;
Periaqueductal gray/physiology;
Analgesia;
Rats
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The paper is to report the results of observations of the relation of analgesia induced by electric stimulation of the hippocampus with the midbrain periaqueductal gray (PAG).The tail flick and vocalization in response to the electric stimulation of the tail skin were used as indices of pain response.The results were as follows.1.The tail-flick threshold produced by electric stimulation of the dorsal and ventral hippocampus and especially the PAG with the same strength of electric current was significantly increased.2.The vocalization threshold induced by the same strength of electric stimulation of the dorsal hippocampus and the PAG was markedly elevated.The stimulation of the dorsal hippocampus elicited more marked response than that of the PAG.The stimulation of the ventral hippocampus induced a far much weaker response than that of both the docsal hippocampus and PAG.3.On the after-effect of analgesia induced by PAG stimulation,the vocalization threshold of dorsal hippocampus stimulation was elevated far more marked than the simple stimulation of the dorsal hippocampus could induce and vice versa.4.The tail-flick and vocalization threshold induced by dorsal hippocampus stimulation,was significantly reduced after the PAG was electrically destroyed.These results show that there is a synergistic action between the analgesic effects produced by the stimulation of the PAG and by stimulation of the dorsal hippocampus,and the analgesic action of the dorsal hippocampus stimulation is completed partly through PAG.
