Effects of Verapamil on Oxygen Transport during Hemorrhagic Shock in Dogs
- VernacularTitle:异搏定(Verapamil)对犬出血性休克氧转运的影响
- Author:
Decheng LUO
- Publication Type:Journal Article
- Keywords:
Verapamil/pharmacodynamics;
Shock;
hemofrhaic/drug therapy;
Oxygen consumption/drug effects;
Myocardium/physiology
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of verapamil on the oxygen transport during a hemorrhagic shock were studied in dogs.The animals were bled from the femoral artery and the mean arterial pressure(mAP)was maintained at 5.33kPa(40 mmHg) for 90 minutes.During the 60 to 80 minutes of hypotension,the animals of the treated group received 3 intravenons injections of verapamil with the dosage of 0.15 mg/kg of body weight,while those of the control received a same amount of normal saline.Then all the blood shed was transfused back to the animals and they were observed for 2 more hours.It was found that the total oxygen consumption of the treated gronp was far much higher than that of the control(P
