A PRELIMINARY STUDY ON IMMUNE REGULATION OF AMMONIUN GLYCYRRHIZANATE
- VernacularTitle:甘草酸单铵免疫药理作用初探
- Author:
Ren ZHANG
;
Jinxuan CHENG
;
Zhengang WANG
- Publication Type:Journal Article
- Keywords:
Ammoniun Glycyrrhizanate;
Immune Regulation;
PGE2, cAMP
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
After mice given Ammoniun Glycyrrhizanate orally, the spleen weight, the number of leukocytes in peripheral circulation and carbon particle cleaning index increased significantly. Rat spleen lymphocytes exposed to 8 x10-7M and 8 x10-10M of Ammoniun Glycyrrhizanate produced levels of PGE that were 1 - 2 -fold greater than that of the control lymphocytes cultured in medium alone. We also found that the levels of PGE2 and cAMP in mice spleen increased significantly after P.O. Ammoninn Glycyrrhizanate, which we suggested might be the mechanisms of immane regulatory functions of Ammoniun Glycyr rhizanate.
