EFFECTS OF GINSENG ROOT SAPONINS ON IMMUNOSUPPRESSION IN TUMOR-BEARING MICE
- VernacularTitle:人参根总皂甙对荷瘤小鼠免疫功能低下的影响
- Author:
Wenxue YUAN
;
Xiaohua SHANG
;
Luting SUN
;
Xuguang LIU
;
Lili ZHANG
- Publication Type:Journal Article
- Keywords:
GRS;
Ehrlich ascites carcinoma ( ERS );
immunosuppression;
cyclophosphamide, mice
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Ginseng root saponins ( GRS ) was extracted from native ginseng.The dosage used was calculated according to the content of saponins.Immunosuppression in mice was induced in 15 days after implar- ting Ehrlich ascites carcinoma (EAC) subcutaneously in armpit, and in 5-11 days after implanting EAC into peritoneal cavity. GRS administered orally 50mg/kg- for 8 days did not prevent the atrophy of the thymus in tumor-bearing mice but rather aggravated it. GRS administered orally 50mg/kg for 14 days partially restored the suppressed phagocytosis of peritoneal macrophages in tumor-bearing mice. GRS administered orally 50mg/kg for 6 days somewhat restored the suppression of hemolysin formation in tumor-bearing mice 5 days after implanting EAC, But GRS given in the same route and dosage for 9 days, showed no effect on the suppression of hemolysin formation. GRS administered orally 50mg/kg for 10 days partially restored the suppression of delayed hypersensitive reaction in tumor-bearing mice.
