ANTI-INFLAMMATORY EFFECT OF d-ISOCHONDRODENDRINE
- VernacularTitle:异谷树碱的抗炎作用
- Author:
Zhigong LIN
;
Wen CAI
;
Xican TANG
- Publication Type:Journal Article
- Keywords:
d-Isochondrodendrine;
Aspirin;
Hhydrocorti sone;
Anti- inflammatory;
Antipyretir
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
d-Isochondordendrine isolated from Cyclea barbate Miers, 400-800 rng/kg ig inhibited the increased vascular permeability induced by ip 0.7% acetic acid in mice or histamine ic 0.05ug/0.05ml in rats. It markedly inhibited the swelling of mouse ear induced by xylene and the edema produced by injection of 1 % carrageenin , fresh egg white or 2.5% formaldehyde 0.lml beneath the plantar surface of hind paw in intact or adrenalectomized rats. It was effective in the cotton-pellet grahuloma inhibition test in rats after daily medica- tion for 6 d. d-lsochondrodendrine could significantly rnduce the leukocyte removal caused by 1 % carrageenin and the fever induced by sc 7% yeast suspension 3 ml/kg in rats
