THE CLINICAL SIGNIFICANCE OF DETERMINATION OF SERUM PEPSINOGENS Ⅰ AND Ⅱ
- VernacularTitle:血清胃蛋白酶原Ⅰ、Ⅱ检验的临床意义
- Author:
Haiou JIN
- Publication Type:Journal Article
- Keywords:
Pepsinogen Peptic ulcer Gastric cancer Atrophic gastritis
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The results of determination of SPgⅠ and SPg Ⅱ in healthy subjects, some cases of gastrointestinal diseases and other diseases were reported. The level of SPgI was lower in the intestinal type of gastric cancer, but not in gastric type of gastric cancer. The severer the degree of atrophy in the gastric fundus glandular mucosa, the lower the level of SPgⅠ. levels of SPgⅠ, SPgⅡ were high in peptic ulcer, especially in the active stage of duodenal ulcer. In addition, low SPgⅠ, SPgⅡ levels were found in patients after gastrectomy or with cirrhosis, and very high levels were found in chronic renal failure. It is suggested that SPgⅠ, SPgⅡ values may be used as a new serological marker for the initial screening test for intestinal type of gastric cancer, for evaluation of the degree of atrophy of gastric glandular mucosa and for follow-up study of atrophic gastritis. It might also serve as a new serological parameter in the etio-logical as well as epidemiological study for duodenal ulcer.
