Changes of Thromboxane and Prostacyclin after Smoke Inhalation Injury in Goats
- VernacularTitle:山羊烟雾吸入性损伤血栓素和前列环素的变化
- Author:
Yuesheng HUANG
- Publication Type:Journal Article
- Keywords:
Goat;
Smoke inhalation injury;
Thromboxane A2;
Prostacyclin;
Extravascular lung water;
Quantity of lymph fluid
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Smoke inhalation injury was inflicted to 13 goats with chrnoic lung lymph fistula. The contents of thromboxane A2(TXA2) and prostacyclin(PGI2) in plasma, lung lymph fluid, and lung tissues were measured in the 6-hour-periodafter injury with radioimmunoassay. Extravascular lung water(EVLW), thequantity of lymph fluid (QL), the ratio of protein contents in lung lymph and plasma(L/P), hemodynamic parameters, blood gases, platelet count and WBCcount were also determined.It was found that EVLW. QL and L/P increased markedly in the 1st hour, reached the peak of elevation in the 2nd hour, and remained higher than the pre-injury level in the 6th hour after injury, which implies the existence of permea-bility pulmonary edema . Both TXA2 and PGI2 also increased markedly after, injury. The changes of TXA2 and TXA2/PGI2 ratio were in parallelto those of EVLW, QL and L/P in time course and in degree, which implies that the changes of TXA2 and PGI2 might play an important role in the genesis of permeability pulmonary edema. The mechanism might be the direct injury of the two substances and/or the precipitation of platelet and WBC aggregation which can release certain chemical mediators to increase the permeability of the capillaries. In addition, TXA2 might also result in the early elevation of pulmonary arterial pressure.
