Effects of 4-DMAP and NaNO_2 on the Hemodynamics of Dogs with Acute Hemorrhage Complicated with Cyanide Poisoning
- VernacularTitle:4-DMAP、NaNO_2对急性失血复合氰化物中毒狗血流动力学的影响
- Author:
Zhengping YU
;
Ziquan OUYANG
- Publication Type:Journal Article
- Keywords:
4-DMAP;
NaNO_2;
Hemorrhage;
Cyanide;
Hemodynamics
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of 4-DMAP and NaNO2 on the hemodynamics of dogs suffering from acute hemorrhage complicated with cyanide poisoning were studied. It was found that the administration of 4-DMAP could brought about an increase of the cardiovascular functions in the experimental animals. Although the increase was temporal and not very impressive, it played an important role to prevent the dogs from developing cardiovascular collapse during the period of observation. On the other hand, the administration of NaNO2 resulted in a transient excitation for 1-2 minutes and then a prolonged and progressive depression of the cardiovascular functions, and all the experimental animals died from cardiovascular failure within 13-19 minutes after NaNO2 injection.The results of this study indicate that 4-DMAP as a therapeutic agent for acute hemorrhage complicated with cyanide poisoning is superior to NaNO2 since the former can produce an excitation of the cardiovascular functions while the latter a progressive depression and eventually a failure of the cardiovascular functions.
