EFFECT OF THE TOTAL SAPONINS OF PANAX NOTOGISENG ON TRANSMITTER RELEAS AT MOUSE MOTOR NERVE TERMINAL
- VernacularTitle:三七总皂甙对小白鼠运动神经末梢递质释放的影响
- Author:
Yongyuan GUAN
- Publication Type:Journal Article
- Keywords:
Panax notogiseng;
Total saponins;
Nifedipine;
Cad- mium;
Quanta release;
Diaphragm;
Calcium channel
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
The effect of the total saponins of panax notogiseng ( PNS ) on transmitter release was studied on mouse diaphragm. The Ca2+ -mediated release evoked by electric stimulation at the nerve terminal or by raised K+ level was markedly reduced by Cd2 + , but not affected by PNS & nifedipine. Also, PNS didn't change the basic frequency of mepp & the Ba2+ entry during depolarization of the terminal. C-ompared with PNS, Cd2 had a significant effect on decreasing Ba2+ entry. These results suggest that PNS can not change spontanous, synchronous or asynchronous release, the Ca2+ channel involved in the transmitter release at the mouse motor nerve terminal belongs in N type Ca2 channel.
