EFFECT OF TOTAL GLYCOSIDE OF CYNANCHUM OTOPHYLLUM SCHNEID ON SYNAPTOSOMAL AMINO ACID CONTENTS AND WHOLE BRAIN ENZYME ACTIVITIES IN MICE
- VernacularTitle:青羊参总甙对小鼠脑突触体中某些氨基酸含量和脑中某些有关酶活性的影响
- Author:
Jianyi LI
;
Tianrui ZHAO
;
Guohua NAN
- Publication Type:Journal Article
- Keywords:
Total glycoside of cynanchum otophyllum schneid( COS);
GABA;
Glutamate;
Aspartate;
Synaptosome;
Enzyme;
Brain
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The total glycoside extracted from the root of cynanchum oiophy-llum schneid ( COS ) has anticonvulsant activity. Its effect on synap-tosomal amino acid contents and brain enzyme activities in mice were studied in this paper. After the ip administration of COS, the content of GABA was increased, and that of Glu and Asp decreased, in synaptosomes of both normal and TSC induced convulsant mice, while the content of Gin remained unchanged. A fall in the activities of GDH, glutaminase and asparaginase in whole brain was seen. No changes were observed in the activities of GPT, GOT and glutamine synthetase.
