EFFECT OF NALOXONE ON .KEMORRHAGIC SHOCK RELATED TO SYMPATHO-ADRENOMEDULLARY SYSTEM
- VernacularTitle:纳洛酮对失血性休克的治疗作用与交感-肾上腺髓质系统的关系
- Author:
Fang HE
;
Mingqi ZHENG
- Publication Type:Journal Article
- Keywords:
Naloxone;
Reserpine;
Phenoxjrbenzamine;
Sympathetic system;
adrenal medulla-, Shock;
rat
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Morphine antagonist naloxone (3mg/kgiv ) induced a rise in blood pressure,pulse pressure & respiratory rate in the rat under hemorrhagic shock. It also improved the survival rate. ?Receptor antagonist pheno-xybenzamine ( 1 mg/kg iv ) or adrenalectomy abolished the beneficial effects of naloxone. Reserpine ( 1 mg/kg ip for 5 d) which depleted catecholamines of periphal sympathetic nervous system could not abolish naloxone effects. Resrpine plus adrenalectomy abolished naloxone actions again. It is suggested that the effect of naloxone on the blood pressure is mainly due to release of catecholamine from adrenalmedu-llary. The results of isolated adrenal perfusion indicated that naloxone could not induce a rise in catecholamine concentration of perfused liquid. It is suggested that the action of naloxone on catecholamine release may not be a result of direct action upontbe chromaffin cells.
