THE RECEPTOR ROLE OF GLYCOPHORIN A DURING THE INVASION OF ERYTHROCYTES BY PLASMODIUM FALCIPARUM
- VernacularTitle:血型糖蛋白A在恶性疟原虫入侵红细胞中的受体作用
- Author:
Shimin ZHANG
- Publication Type:Journal Article
- Keywords:
glycophorin A;
Plasmodium falciparum;
receptor
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Glycophorin A(GPA)of human erythrocyte membrane is closely related with the invasion of erythrocytes by Plasmodium falciparum. Under the condition of the in vitro culture, the effects of GPA, anti-GPA-IgG, ?1-acid glycoprotein, wheat germ agglutinin, etc. on the invasion of erythrocytes by Plasmodium falciparum were observed in the research. The results showed that the combination of GPA with Plasmodium falciparum merozoites has high specificity, high affinity and a tendency to saturation, and produces specific biological effects. These confirm for the first time from the characteristics of the ligand-receptor interaction that GPA is a recptor recognized and bound by Plasmodium falciparum merozoites.
