ESTABLISHMENT OF THE FIBROBLAST CELL LINE IN THE XERODERMA PIGMENTOSUM PATIENT AND A STUDY OF ITS BIOLOGICAL CHARACTERISTICS
- VernacularTitle:着色性干皮病皮肤成纤维细胞系(XP4SH)的建立及其生物学特性
- Author:
Zuoshu JIANG
- Publication Type:Journal Article
- Keywords:
xeroderma pigmentosum;
fibroblast cell
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Xeroderma pigmentosum (XP; is an inborn autosomal recessive inheritance disease with DNA repair deficiency. XP has become an ideal experimental model to study human DNA repair system and the mechanism of cancer. XP 4SH cell line in this report was obtained from the skin tissue of XP patients. After cell culture, XP 4SH cell line showed the characteristics of form and growth of fibroblast cell. The number of its chromosome was 46(2n = 46).Its aberration was characterised by dicchro-mosomes appearing in XP cells. XP cells induced by UV showed that the frequency of SCE increased significantly while the level of UDS decreased. Gene complement analysis by cell fusion suggests that XP 4SH cell line belongs to the complementation group A.
