THE SPECIES DIFFERENCE OF ATRIOPEPTIN I ACTION ON THE BLOOD VESSELS
- VernacularTitle:心房肽Ⅲ对人体血管作用的差异性
- Author:
Wenshu HU
;
Jizhou XIANG
;
Mingxing JIANG
- Publication Type:Journal Article
- Keywords:
Atriopeptin I;
Sodium nitroprusside;
agonist;
umbi- lical artery;
gastroepiploica dextral artery;
thoracic aorta;
nonsp- ecific antagonist.
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The present experiments were designed to investigate the effects of atriopeptin I on different vascular smooth muscles.Isometric tension was recorded from spiral strips of human umbilical arteries, gastro-epiploica dextral arteries, rat and rabbit aorta. Atriopeptin H showed a potent inhibitor on the contraction induced by noradrenaline ( 3tmol/l), Serotonin ( lnmol/1), hista-mine ( 10M-mol/l ) and phenylephrine ( l(imol/l)in the strips of rat and rabbit aorta, but not on the contraction induced by the above-mentioned drugs and KC1 (80mmol/l), prostaglandine F2a ( 10umol /I) in umbilical and gastroepiploica dextral arteries of human beings. Sodium nitroprussids showed also a potent antagonist on the contraction induced by noradrenaline ( 3 M-mol/1) serotonin ( 1imol/l), histamine (10imol/1) and prostaglandine F2a (10nmol/l) in the strips of umbilical arteries.lt produced concentration-dependent inhibition of the contraction induced by noradrenaline.It could remarkably decrease the resting tension of the strips.The present results suggest that atriopeptin I exhibits a similar vasodilator profile in rat and rabbit aorta as that found for sodium nitroprusside in the human umbilical arteries.The ineffectiveness of atriopeptin I on human umbilicalj and gas-troepiploica dextral arteries is in marked contrast to the effectiveness of sodium nitroprusside in the human umbilical arteries, indicating that the action of atriopeptin f possesses species difference.
