STUDIES OF HYPOTENSIVE RESPONSE OF NITRENDIPINE, MNIFEDIPINE AND THEIR OIL PREPARATION
- VernacularTitle:尼群的平、间硝苯吡啶及其油剂降压特点的研究
- Author:
Manren RAO
;
Shenglan JIA
- Publication Type:Journal Article
- Keywords:
Nitrendipine;
m-nifedipine renal hypertensive rats;
an- tihypertensive action.
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The present experiments were designed to compare the antihypert-ensive effects of nitrendipine, m-nifedipine and their oil preparation in conscious renal hypertensive rats The left renal artery was narrowed by a silver clip of 0.2mm diameter under anaesthesia.The systolic blood pressure was measured by the tail cuff method. Nitrendipine and m-nifedipine dissolved in peanut oil ( 20mg/ml ) ; 20mg/kg were given im every other day for 4 weeks.Using sum of squares of deviations from mean in comparison with the untreated control animals the results showed that the 2 drugs reduced the blood pressure significantly (P
