DISTRIBUTION AND METABOLISM OF [~3H] CMCa IN S_(180) BEARING MICE
- VernacularTitle:[~3H]甲硝唑氨酸钙在荷S_(180)小鼠体内的分布与代谢
- Author:
Xiulong ZHENG
- Publication Type:Journal Article
- Keywords:
[3~H]CMCa;
metronidazole;
sarcoma 180;
tissue distribution;
drug metabolism
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The blood radioactivity-time curve after iv [3H] CMCa in S180 bearing mice was found to be diexponential model.Pharmacokinetic parameters; t1/2 ?=9.6min, t1/2 P=37 h.It was quite rapidly distributed from the central compartment to the peripheral compartment.The highest radioactivity and the slowest metabolic rate were found in tumor.It further confirmed our foregoing result that this drug could concentrate in tumor,and was lower in brain with decreased neurotoxicity.The metabolic rates of the drug in blood and muscle were quite rapid, indicating it might be useful for clinical diagnosis and therapy of tumor.The results analyzed by TLC and scintillation counting of urine taken 24 h after iv [3H] CMCa to S180 bearing mice indicated that approximately 80% of urine total radioactivity was excreted as original drug in unchanged form and 7% as its hydrolyzate metronidazol.These results were similar to those in normal mice.
