MOBILIZATION OF HEIVIATOPOIETIC STEIVl CELLS INTO PERIPHERAL BLOOD OF MICE BY ENDOTOXIN
- VernacularTitle:内毒素对造血细胞的动员
- Author:
Jin ZHANG
- Publication Type:Journal Article
- Keywords:
endotoxin;
hematopoietic stem cell mobilization
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Mobilization of pluripotent hematopoietic stem cells (CFU-S) into circulation by Ch violaceum endotoxin, and the relationship between sensitivity to endotoxin and the mobilization were studied in mice.It was observed that the circulating CFU-S per 106 MNC had a 2-fold increase on the 5th day after endotoxin.The mobilization of progenitor cells (CFU-GM) by endotoxin was more evident in ICR mice, whichwere more sensitive to endotoxin, than in Kunmin mice.Endotoxin could mobilize more CFU-GM in mice whose sensitivity to endotoxin had been elevated by pretreat-ment with BCG.On the basis of these results, we conclude that the BCG-pretreatment may be an effective measure to raise the yield of CFU-GM.
