EFFECTS OF SINOMENINE ON ISOPRENALINE AND CALCIUM MEDIATED POSITIVE CHRONOTROPIC ACTION
- VernacularTitle:青藤碱对异丙肾上腺素、组胺及氯化钙正性频率作用的影响
- Author:
Chaoxing LI
;
Gengsfaeng ZHAO
- Publication Type:Journal Article
- Keywords:
Sinomenine;
Atriuni;
Negative, chronotropic;
Ooseres- ponse relationship;
Calaium channel blocking activity
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of sinomenine (Sin) on isoprenaline and hist ami no dose-response relationships and calcium-mediated positive chronotro-pic time-response relationship were studied in isolated guinea-pig ri^lil atritui. Sin shifted isoprenaline and histamine doseresponse cuives to the right non-parallely and depressed their maximum and produced a noncompetitive antagonism. The pD'2 values were 3.48+ 0.08 and 3.63+0.04, respectively. It was different from B-receptor blocker propranolol and H2-receptor blocker cimetidinc. Sin as well as verapamil antagonized the positive chronotropic response to CaCl2. These results suggested that the negative chrouotropic effects of Sin did not result from blocked |3-and H2-receptor, but probably from antagonizing Ca2+ channel.
