Practical Criteria for Prediction of Responses to Chemotherapy in 90 patients with Acute Leukemias
- VernacularTitle:临床预测急性白血病疗效的实用指标
- Author:
Kunrong WANG
- Publication Type:Journal Article
- Keywords:
Acute leukemia;
Clinical criteria;
Chemotherapy;
Blood picture;
Bone marrow picture;
Marrow blast decrease index
- From:Journal of Third Military Medical University
1986;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
Five clinical criteria, including the size of the liver, spleen, and lymph nodes, tenderness over the sternum, and hemorrhagic tendency, the white cell and platelet counts, the bone marrow picture, and the marrow blast decrease index (MBDI) were studied in 90 patients with acute leukemia prior to and after chemotherapy to predict the therapeutic effects.It is concluded that in the 4th week after the commencement of chemotherapy, if there is amelioration of the 5 clinical criteria, steady increase of platelets or with a rebounding peak, improvement of the bone marrow proliferation, and MBDI over 41%, it is an indication that there will be a remission of the disease. If, on the contrary, the 5 criteria shows no amelioration, the white count exceeds 50?109/L, the platelet count decreases markedly, bone marrow proliferation demonstrates no improvement, and MBDI is below 40%, then the possibility to have remission is very little.This method for the prediction the therapeutic responses in leukemic patients is simple, practical, and reliable. The comprehensive analysis of the 9 items cai exercise the function of mutual compensation and render the prediction more precise
