CLINICAL OBSERVATION OF THERAPEUTIC EFFECTS OF ALLOSTERIC SNAKE NEUROTOXIN SN 114 CASES OF MOTOR NEURON DISEASE

VernacularTitle:变构蛇神经毒素治疗运动神经元病114例的临床观察
Author: Guiqing WANG
Publication Type:Journal Article
Keywords: allosteric snake neurotoxin motor neuron disease nicotinic acetylcholine receptor
From: Academic Journal of Second Military Medical University 1985;0(06):-
CountryChina
Language:Chinese
Abstract: This paper reports the efficacy of allosteric snake neurotoxin in the treatment of 114 cases of motor neuron disease. The drug was given intramuscularly once a day with a dose of 2 ml (500 ?g/ml) in 68 cases of amyotrophic lateral sclerosis, 40 cases of progressive muscular atrophy and 6 cases of primary lateral sclerosis. Eighty-three cases were followed up from 3 to 28 months. The recent therapeutic effects observed were as follows : there was some improvement in 20 cases (24.1%), stability of disease in 26 cases (31.3%) and no effect in 37 cases (44.6%).The clinical effectiveness of modified neurotoxin is evaluated and the possible mechanism of its therapeutic action is also discussed.