EFFECTS OF INJECTION OF SALVIA MILTIORRHIZA (ISM) ON LIVER BLOOD FLOW & LIVER INJURY IN MICE & RATS INTOXICATED WITH CARBON TETRACHLORIDE
- VernacularTitle:丹参注射液对四氯化碳中毒小鼠、大鼠肝脏血流量及肝损伤的作用
- Author:
Tingxin ZHANG
;
Meng LI
;
Fengsheng ZHANG
- Publication Type:Journal Article
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Liver blood flow was measured in normal & CCl4-intoxicated mice & rats, using the electrolysis-generated hydrogen gas method. The results showed that the intramuscular injection of 6-15/kg of ISM increased significantly the liver blood flow in normal mice & rats. In acute or chronic CCl4-intoxicated mice & rats, the liver blood was decreased but the blood flow was restored the normal level by the ISM. In addition, the protective effect against liver injury was also observed by the histological examination & electron micrographs.The above results suggest that the protective effect of ISM against CCl4-induced liver injury seems to be through increasing the liver blood flow, improving liver's microcirculation & preventing or mitgating the denaturing or necrosis of liver cells.
