EFFECTS OF MALOTILATE ON ACUTE LIVER INJURY INDUCED BY CARBON TETRACHLORIDE AND D-GALACTOSA-MINE IN MICE
- VernacularTitle:Malotilate对四氯化碳及D-半乳糖胺引起的小鼠急性肝损伤的影响
- Author:
Zhibin LIN
;
Dong XIA
- Publication Type:Journal Article
- Keywords:
Malotilate;
CC1_4;
D-galactosamine;
SGPT;
Serum protein;
Hepatic protein;
Hepatic glycogen;
Hepatic trigiyceride;
Cytochrome P-450
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
A study was made; of the effect of malotilate on the acute liver injury induced by carbon tetrachlorid,e ( CC14 ) and d-galactosamine in mice. Malotilate ( 50~150mg/kg ig?3 ) significantly inhibited the elevation of serum glu tamic pyruvic transaminase ( SGPT ) in CC14- intoxicated mice.At the dose of 100mg/kg ig?3, malotilate remarkably increased the content of hepatic glycogea in CCl4-injected mice. The contents of serum protein, liver protein, and cytochrom P-450 in liver hemogenate were increased by malotilate ( 100mg/kg ig?3) in CC14-intoxicated mice. The drug also reduced the accumulation of liver triglycerides induced by CCl4 in mice.In addition to, malotilate(50mg /kg, ip?5) could act against the increase of SGPT and the decrease of liver protein content induced with d-galactosamine in mice. These results suggest that malotilate may be a new therapeutic agent for liver injury.
