EFFECT OF GLONIDINE ON MURINE LYMPHOCYTE TRANS-FORMATION IN VITRO
- VernacularTitle:可乐定对小鼠体外淋巴细胞转化的影响
- Author:
Yongxiang WANG
;
Mingzhu CHEN
;
Shuyun XU
- Publication Type:Journal Article
- Keywords:
clonidine;
T lympocyte transformation;
mouse
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
A postulated suppression of T lymphocyte function by clonidine (an adrenogic receptor agonist) was explored by utilizing mitogen induced lymphocyte transformation of mouse spleen cells in vitro. Added at the onset of the culture or 24h later, clonidine (10-(?)-10-8 M ) did not suppress T lymphocyte transformation induced by ConA or PHA. It implies that there is a difference in the sensitivity for clonidine between T and B lymphocyte, as clonidine has been suggested to suppress the SRBC induced primary immune response of mouse spleen cells in a dose dependent manner.
