STUDIES ON THE CHEMISTRY OF PHOTOCARCINQRIN
- VernacularTitle:癌光啉的化学研究
- Author:
Deyu XU
- Publication Type:Journal Article
- Keywords:
hematoporphyrins hematoporphyrin derivative tumor photolocaliz-ation photochemodiagnosis photochernotherapy photodynamic effect hematoporphyrin photosensitizer photocarcinorin
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The preparation,chemical composition and physicochemical properties of photocar-cinorin (PsD-007),a new drug of photolocalizaion and photochemotherapy for human malignancies,are reported here.It has been shown by the resul s of thin layer and high performance liquid chromatographic (TLC & HPLC) analyses that about 85% of its total weight are relatively hydrophobic porphyrins of unknown structure in which a fraction with the same retention time as .hematoporphyrin(Hp)monoacetate constituts over 60%.There are also 4.2% of Hp,8.6% of 3(8) hydroxycthy lS-(3)-vinyldcutero-porphyrin (HVD) and 0.6% of portoporphyrin (Pp) in this drug.The presence and amount of HVD in PsD-007 were determined by an authentic sample prepared in our laboratory.The changes of the composition of PsD-007 on exposure to different doses of argon laser (488+ 514.5nm) were detected by HPLC.The variations in Soret peak of UV absorption spectra of PsD-007 protected from light at a constant temperature were also determined
