DEVELOPMENT OF HYDROXYPIPERAQUINE-RESISTANT LINE OF PLASMODIUM BERGHEI ANKA STRAIN
- VernacularTitle:伯氏疟原虫ANKA株抗羟基喹哌系的培育
- Author:
Zurui DAI
- Publication Type:Journal Article
- Keywords:
hydroxypiperaquine-resistant line Plasmodium berghei ultrastructure
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
In this paper,we report the method and results of the development of hydroxy-piperaquine-resistant line of Plasmodium bergkei ANKA strain.Under the drug pressure,by mice to mice syringe passages its resistance index was 136-fold after 6 passages (HPR/ANKA),and through serial mice-mosquitoes-mice cyclical passages,from this line developed a new line (MHPR/ANKA) with a resistance index of about 129-fold. Drug sensitivity tests were performed in HPR/ANKA (60 times resistant toI hydroxypiperaquine),and the resistance indices to piperaquine and artesunate (804)were higher than that to chloroquine,pyronaridine and nitroquine.In the formergroup,the resistance indices were 26.8 and 10.1 respectively,and 4.1,1.1 and 0.7respectively in the latter one.
