Observations on Pulmonary infrastructures in Experimental Respiratory Distress Syndrome Treated with Anisodamine in Dogs
- VernacularTitle:山莨菪碱治疗实验性犬呼吸窘迫综合征肺脏超微结构观察
- Author:
Conglian CHEN
;
Jingquan SHI
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome;
Anisodamine;
PulmonaryUltrastructure;
Pulmonary edema;
Hyaline membrane;
Pinosome;
Complement;
C5a
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Experimental respiratory distress syndrome was induced with oleic acid injection to 8 dogs. 4 dogs received no treatment and served as controls, and the other 4 were treated with anisodamine (654-2) after oleic acid injection.All the animals were killed at the 72nd hour after injection, and their lung tissues were studied under electron microscope.It was found that anisodamine was able to reduce the severity of pulmonary edema. There was accumulation of neutrophils in the pulmonary capillaries and hyaline membrane formation on the epithelial surface of the alveoli and alveolar duct walls. Neutrophil accumulation in the capillaries may indicate that the content of the blood was kept at a fairly high level at the 72nd hour after injection in spite of anisodamine treatment. The chief constituent of the hyaline membrane was fibrin. At the sites of hyaline membrane formation, focal cyto-plasmic necrosis of the type I epithelial cells was often observed.
