EFFECTS OF HEPATOCELLULAR TRANSPLANTATION ON ACUTE LIVER FAILURE IN RATS
- VernacularTitle:移植肝细胞治疗大鼠急性肝衰竭的研究
- Author:
Lingzhi ZHANG
- Publication Type:Journal Article
- Keywords:
transplantation acute hepatic necrosis D-galactosamine hepatocyte disease models, animal rats
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
In this study, acute liver failure was induced in rats by d-galactosamine (D-GalN) injection. Intraperitoneal injection,24 h later, of viable syngeneic hepatocytes apparently increased the survival rate of these animals (48%), while transplantation of non-viable hepatocytes was ineffective and even showed a certain degree of clotting disorders.A microscopical observation of the liver specimens and estimation of DNA synthesis cy 3H-TdR suggest that viable hepatocellular transplantation may minimize the hepatic injury and promote hepatic cell regeneration.
