EFFECTS OF TESTOSTERONE OR ESTRADIOL AND COLCHICINE ON TOXIC HEPATIC NECROSIS IN DIFFERENT SEXUAL MICE
- VernacularTitle:性激素与秋水仙碱对不同性别小鼠中毒性肝坏死的作用
- Author:
Mingxing ZHOU
- Publication Type:Journal Article
- Keywords:
testosterone estradiol colchicine liver necrosis disease models, animal mice
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Toxic hepatic necrosis (THN) was induced in BALB/C mice by CCl4 infection (i.p.) and then colchicine (orally), testosterone propionate or estradiol valerate (s.c.) were administered. The experimental results reveal that the effect of colchicine on THN was better in male mice than that in femalemice.Testosterone propionate had no effect on the survival rate of male and female mice with THN, but enhanced the therapeutic effect of colchicine on THN in female mice. All male mice with estradiol died and half of them with estradiol and colchicine survived(P
