ANTIPLATELET EFFECTS OF PILOCARPINE
- VernacularTitle:毛果芸香碱的抗血小板作用的探讨
- Author:
Zhonglu CHU
- Publication Type:Journal Article
- Keywords:
pilocarpine platelet aggregation platelet deaggregation interplatelet bridge
- From:
Academic Journal of Second Military Medical University
1981;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
After the antiaggregatory effect of pilocarpine on platelets was discovered, we continued to demonstrate its other effects on platelets. The results of the experiments with rabbit platelets were as follows. (1)Pilocarpine inhibited platelet aggregation and ATP secretion induced by ADP, arachidonate and collagen; it inhibited platelet shape change induced by collagen, but not by ADP and arachidonate. (2)Pilocarpine deaggregated the platelet aggregates induced by ADP and arachidonate, but had no such effect on those induced by collagen. The interplatelet bridge demonstrated by Nachman et al can not reasonably explain the latter phenomenon, we suggest two hypothetical models of interplatelet bridge with glycoprotein G(GPG)as a component.