STUDY ON CLINICAL PHARMACOKINETICS OF THE NEW PHO- TOSENSITSZER PHOTOCARCINORIN FOR TUMOR LOCALIZATION AND PHOTORADIATION THERAPY
- VernacularTitle:癌光啉静脉滴注后的临床药物动力学研究
- Author:
Yunzhang XU
- Publication Type:Journal Article
- Keywords:
photocarcinorin clinical pharmacokinetics hematoporphyrin derivative three-compartment model
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The clinical pharmacokinetic behavior of new photosensitizer photocarcinorin for the photoradiation therapy of 11 patients with different malignant tumors was studied by means of fluorospectrophotometric method after intravenous infusion.The dose infused was 4-4.5 mg/kg body weight and the infusion rate, 0.1 mg/ kg/min.It is a three-compartment model as determined by the drug-time curve through Akaike's Information Criterion(AIC) .The principal pharmacokinetic parameters calculated by nonlinear least-square regression program are: t1/2? = 0.26?0.05h, t1/2? = 4.52?1.04h, t1/2?=32.9?5.31h.In addition, the pharmacokinetic parameters of one patient injected with lower dose(1.82 mg/kg)were also determined, and shown as a three compartment model.
