STUDIES ON THIN-LAYER CHROMATOGRAPHY OF THE HEMATO-PORPHYRIN PHOTOSENSITIZERS PSD-001 AND PHOTOCARCINORIN
- VernacularTitle:光敏剂PSD-001及癌光啉的薄层色谱分析研究
- Author:
Xiong CHEN
- Publication Type:Journal Article
- Keywords:
thin layer chromatography hematoporphyrin hematoporphyrins derivative photofrin II hematoporphyrin photosensitizer protopor- phyrins d-uteroporphyrins
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The separation and analysis of hematoporphyrin photosensitizers PSD-001, photocarcinorin,photofrin II and other HPD preparations in comparison with authentic samples protoporphyrin (PP), 3-(8)-(1-hydroxyethyl) -8-(3-)-vinyldeuteroporphyrin ( HVD)and hematoporphyrin(HP) using thin layer chromatography(TLC) under different conditions are described here.It has been shown that there are 3 and 2 main spots in PSD-001 and photocarcinorin by common TLC, but 8-9 spots by high performance TLC.It has been found by comparison with authentic HP,HVD and PP that the amount of PP in PSD-001 or photocarcinorin is less than 3% and HVD,about 2.5% and 6.3% respectively,the HP content of photocarcinorin is much lower than other photosensitizers mentioned above and there is not any component near the origin spot.The Rf of one of the major components of photocarcinorin is 0.65.This component seems to be hardly found in other photosensitizers.These suggest that photocarcinorin is a new photosensitizing agent differing from HPD and photofrin II.
