MMUMOFLUORESCENT, ULTRASTRUCTURAL AND HISTOCHEMICAL STUDIES ON CELLS INFILTRATING HEPATOCELLULAR CARCINOMA AND PERITUMOUR LIVER TISSUES
- VernacularTitle:原发性肝癌及其癌周组织中浸润细胞的免疫荧光、超微形态和组织化学研究
- Author:
Yajun GUO
- Publication Type:Journal Article
- Keywords:
hepatoma T lymphocyte infiltration immunity infrastructure histochemistry
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
In the present study, lymphocyte subpopulations, plasma cells and macrophages infiltrating hepatocellular carcinoma (HCC) and peritumor liver tissues from 78 patients were identified and characterized using a specific immunofluorescent technique with anti-human T lymphocyte globulin(ATG), anti-human B lymphocyte globulin (ABG), antihuman IgG, IgM, IgA serum,and ?-naphthyl esterase staining method. The liver specimen from 9 patients with cirrhosis and 19 healthy persons were selected as control groups. Ultrastructural morphology was electromicroscopically observed sometime. The majority of cells infiltrating cancer tissue were T cells (74%) which selectively accumulated in the zone between cancer and noncancer liver tissue and arranged around cancer tissue in a row way. T cells might kill cancer cells in different ways. This results indicate that the local lymphocyte and macrophage infiltration is a specific immune reaction against HCC.
