THE PROTECTIVE AND THERAPEUTIC EFFECT OF 4-MERCURIC ACETATE ESTRONE ON DOGS WHICH RECEIVED 2.75Gy ~(60)Co ?-RAY IRRADIATION
- VernacularTitle:4-醋酸汞雌酚酮(4-ME_1)对2.75Gy照射狗的防治作用
- Author:
Jinsong XIAO
- Publication Type:Journal Article
- Keywords:
estrone radiation therapeutics dogs
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
4-Mercuric acetate estrone (4-MF1) is one of steroidal estrogens which have hi-her protective and therapeutic effects on dogs receiving 2.75 Gy of 60Co ?-ray iradiation.Among those experimental groups,the group treated with 4-ME1 15 mg i.m. two days before irradiation had the higest protective effect, all 5 dogs survived;The group treated with 4-ME 1 i.m. twice at 6,48 h after irradiation had the best therapeutic effect. The survival rate was elevated 54.4%(9/15), as compared with the control group.The clinical symptoms were milder, survival time of dead animals longer, and the WBC count higher.
