Effects of Hypoxia and Endotoxin on Pulmonary Pressor Response and Lung Fluid Exchange in Conscious Goats
- VernacularTitle:缺氧、内毒素对清醒山羊肺动脉增压反应和肺内液体交换的影响
- Author:
Xilin CHEN
- Publication Type:Journal Article
- Keywords:
Hypoxia;
Endotoxin;
Lymph;
Pulmonary circulation;
Altitude
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of hypoxia and endotoxin, acting alone or in combination, on pulmonary pressor response and lung fluid exchange were studied in 9 conscious goats. Hypoxia(simulating a high altitude of 4,000 m for 5 hours) elevated the pulmonary arterial pressure, but exerted no effect on lung lymph flow, the protein concentration ratio between lymph and plasma, and the clearance rate of lung lymph protein. Three stages were noted after endotoxin injection; the phase of pulmonary hypertension, the phase of pulmonary microvascular injury, and the phase of increased pulmonary microvascular permeability. No obvious difference was observed when endotoxin was acting alone or in combination with hypoxia.The results suggest that 1) the mechanism of pulmonary pressor response induced by hypoxia is somewhat different from that induced by endotoxin, 2)no obvious increase in pulmonary microvascular permeability was noticed during hypobaric hypoxia, and 3) alveolar hypoxia could not enhance the endotoxin-induced lung injury.
