EFFECTS OF INTERFERON ON MITOMYCIN-INDUCED SISTER CHROMATID EXCHANGES AND ON ULTRAVIOLET-LIGHT-INDUCED UNSCHEDULED DNA SYNE THESIS

VernacularTitle:干扰素对丝裂霉素C诱发的姊妹染色单体互换和紫外线诱发的DNA修复合成影响的研究
Author: Xiaopeng WANG
Publication Type:Journal Article
Keywords: xeroderma pigmentosum interferon sister chromatid exchange DNA repair mutagens
From: Academic Journal of Second Military Medical University 1985;0(06):-
CountryChina
Language:Chinese
Abstract: We studied the effects of interferon(IFN) on sister chromatid exchanges(SCE) induced by mitomycin(MMC) and/or on unscheduled DNA synthesis(UDS ) induced by ultraviolet light(UV) in peripheral lymphocytes taken from 4 normal individuals and 3 patients with xeroderma pigmentosum(XP) in whom the existence of congenital DNA excision repair defect had been verified.The lymphocytes from 2 normal individuals and 3 patients with XP were treated with IFN 8 hours before MMC was added SCE frequencies in IFN groups were lower than those in the controls. Statistical computation showed that all differences were highiy significant(P0.05).