STUDIES ON EARLY DIAGNOSIS OF HEPATOCELLULAR CANCER WITH MICRO-HETEROGENEITY OF ALPHA-FETOPROTEIN
- VernacularTitle:甲胎蛋白异质体对原发性肝癌早期诊断的研究
- Author:
Zhenxing TU
- Publication Type:Journal Article
- Keywords:
alpha fetoproteins heterogeneity hepatoma diagnosis immunoelectrophoresis
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Microheterogeneity of alpha-fetoprotein (AFP) in the sera of 78 patients with hepatocellular cancer (HCC) and 40 patients with benign liver diseases (BLD) was studied by lectin affino-immunoelectrophoresis autoradiography. Serum AFP concentre tions varied 124-56000ng/ml in patients with HCC and 31-980 ng/ml in patient with BLD.By means of either LCA or Con-A, AFP was divided into two variants, which were coded AFP-R-L (AFP retarded by LCA) and AFP-N-L (AFP not retarded by LCA), AFP-R-C (AFP retarded by Con-A) and AFP-N-C (AFP not retarded by Con-A), respectivily. AFP-N-L percentage lower than 75% was observed in 87.2% of patients with HCC and none with BLD, AFP-R-C percentage lower than 100% in 89.7% of cases with HCC and 17.5% of patients with BLD. According to the diagnostic standard of AFP level greater than 400ng/ml for primary liver cancer, the positive rate of patients with HCC was 78.2%, and that of patients with BLD was 20.0%. Determination of microheterogeneity of AFP ran raise the positive rate of patients with HCC to 97.4% and reduce that of patients with BLD to O (by mean of LCA). Therefore, determining the concentrations of AFP variants can increase the clinic value of AFP as a marker of primary liver cancer.
